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KMID : 0191120180330500299
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Journal of Korean Medical Science
2018 Volume.33 No. 50 p.299 ~ p.299
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Presence of Sarcopenia and Its Rate of Change Are Independently Associated with Long-term Mortality in Patients with Liver Cirrhosis
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Jeong Jae-Yoon
Lim Sang-Hyeok
Sohn Joo-Hyun
Lee Jae-Gon
Jun Dae-Won
Kim Yong-Soo
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Abstract
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Background: Sarcopenia is associated with a poor prognosis in patients with liver cirrhosis. However, it is not known whether the rate of skeletal muscle depletion is also associated with a poor prognosis. We investigated the prognostic impact of the rate of skeletal muscle depletion in patients with liver cirrhosis.
Methods: We included retrospectively all patients with liver cirrhosis who underwent both multiple computed tomography scans and hepatic venous pressure gradient (HVPG) measurements.
Results: A total of 131 patients with liver cirrhosis were enrolled. The mean age of the patients was 53.7 years and alcoholic liver disease was the most common cause (61.8%). Sixty-four patients (48.9%) were diagnosed with sarcopenia. The median changes in skeletal muscle area per year (ΔSMA/y) were ?0.89%. During a median follow-up period of 46.2 months (range, 3.4?87.6), 45 patients (34.4%) died. In multivariate analyses, age, Child-Pugh score, HVPG, presence of sarcopenia and ΔSMA/y were independently associated with mortality. Cumulative mortality was significantly higher in patients with ΔSMA/y < ?2.4% than those with ΔSMA/y ≥ ?2.4% (log-rank test, P < 0.001).
Conclusion: Both the presence and rate of change of sarcopenia are independently associated with long-term mortality in patients with liver cirrhosis.
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KEYWORD
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Liver Cirrhosis, Sarcopenia, Nutrition, Mortality, Prognosis
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